Generic brand diflucan /sulfacetamide) in the present study. Previous clinical trial and cohort studies a large placebo-controlled drug safety trial conducted in women the Netherlands have demonstrated positive effects of oral magnesium sulfate and diflucan on cervical dysplasia.15,17–19 In our study, only the magnesium-containing tablets (0.5, 1.0, and 1.5 g/day) were taken during the first 6.4 weeks, at end of which the dosage was increased at weekly increments to a maximum of 7.5 g/day during the last 6.7 weeks. In addition, all women who developed cervical dysplasia were excluded from the trials and case reports as this was not deemed clinically important. It seems reasonable to suggest that supplementation of magnesium should be advised for women who are at risk of developing cervical dysplasia. However, the study was limited in that only a small fraction of women had an increased risk at any month of supplementation and only one type of supplementation was administered, magnesium sulfate, which had previously been found to reduce the incidence of cervical dysplasia.6,7 This would suggest that approach to reducing the incidence of cervical dysplasia would lead to an increased risk of developing cervical dysplasia, but we do not know whether this would be true in a subgroup of women. The study was also not randomised and the results have to be interpreted with caution if women who have abnormal endometrial epithelium at the time of evaluation (e.g., cervical biopsy) and/or an abnormal Pap smear are excluded.20 A limitation of the study is that baseline was not designed to investigate vitamin D status, and therefore supplementation did not occur during the intervention period. Women with reduced vitamin D levels in the trial period could be at an increased risk of cervical dysplasia compared with women who were vitamin D sufficient, and it is therefore possible that the findings were not due to vitamin D. Furthermore, there was a limited number of women whose baseline vitamin D level did not fall outside the normal range (6.3–25.8 nmol/l). Women who have altered vitamin D levels been shown to have an increased risk of endometrial cancer (OR=1.6) and therefore we could not conclude that vitamin D deficiency was also associated with an increased chance of developing cervical dysplasia. Clinical concerns related to the risk of cervical dysplasia and endometrial cancer in women with magnesium deficiency who take a daily dose of 0.5 g/day magnesium oxide, including its ability to protect against endometrial carcinoma,22,23 should be considered carefully with future trials. In addition, magnesium oxide may have its toxicity more effectively through direct oral absorption due to the high levels of calcium present, thereby limiting its usefulness in a preventive context. This also highlights the importance of an adequate intake vitamin D through sunshine, as some studies suggest that women who use sunbeds have a higher incidence of endometrial cancer.24 In conclusion, this study confirms the results from first clinical trial that daily supplementation of magnesium sulphate for buy diflucan online usa 6 weeks significantly reduced cervical dysplasia in women and provides further evidence that oral magnesium can be beneficial in a preventive context to reduce the incidence of cervical dysplasia. We recommend that magnesium should be investigated for its effectiveness and safety in preventing cervical dysplasia women with normal-range vitamin D levels, especially in the case of people who are at an increased risk of developing cervical dysplasia.
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