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A study was conducted to determine whether use of acetaminophen increases the incidence stroke in patients at increased risk and in women taking oral contraceptives.
Results:
A total of 609 patients were enrolled and randomly assigned to acetaminophen only (placebo) or oral contraceptives (OC) group for 3 years. The incidence of stroke among those not taking OC was significantly higher in the acetaminophen compared with OC group (odds ratio [OR] 0.69; 95% confidence interval [CI] 0.52 to 0.91; P =.006). There were no cases of stroke in the OC group. incidence of recurrent stroke was 2.9 times higher among the OC group during 6 years of active comparison than among those in the placebo group (OR 3.05; 95% CI 1.41 to 6.00; P =.04).
Conclusion:
Use of acetaminophen could be expected to increase the risk of stroke in women who are at increased risk, and the risk appears to be higher in women on OC.
Risk of death by oral contraceptive use in the first 4 years of use; and risk death by oral contraceptive use in the 3 years after cessation of use.
This study is unique in its focus Deltasone 5mg $63.84 - $0.35 Per pill on an important cohort: women who are taking oral contraceptives for the first 4 years of use and for at least 3 years after they have been stopped (i.e., for a total of 8 years).
Key Findings:
Only 27% of women taking oral contraceptives are in the postmenopausal period.
The risk of death by oral contraceptive use for the first 4 years after stopping use was 0.11. The risk elevated for women taking oral contraceptives 3 years or more after stopping use: 0.21 for women in the first year and 0.22 for women in the 3rd, 5th, and 6th years after stopping use.
It was observed that the risk of death by oral contraceptive use in the 2 years after stopping use (before and the of oral contraceptive) was 0.15 for the first year (after stopping use of oral contraceptives) and 0.16 for the remaining months.
Conclusion:
The number of women using oral contraceptives, especially the 4-year period, is small. In these studies, the risk of death was elevated during the first year after stopping use of the oral contraceptive. risk death was increased for 3 years or more after stopping use of oral contraceptives. These data suggest that if a woman is taking oral contraceptives continuously for more than 4 years, she should continue taking them.
Risk of death by oral contraceptive use and age before starting oral contraceptives
This study compared the risks for women who used oral contraception for the first time during their teenage or early 20s (youngest age in this study), and compared these risks to the risk of death for women starting oral contraceptives at or below the age of 20, before these women developed reproductive functions.
Results:
The risk of death was increased in the first year (RR 2.12) and thereafter.
Conclusion:
The use of oral contraceptives before 20 is likely the most important factor for development of fertility problems within that women.
Risk factors for hemorrhagic (bleeding) stroke as a secondary risk after oral contraceptives cessation
The number of women participating in the study was limited to 2256 for this article due to ethical concerns. However, these data suggest that some of the risks associated with discontinuing oral contraceptives are similar to those seen in women who developed a hemorrhagic stroke.
Background:
The risk of hemorrhagic stroke is approximately 50% of the risk among women who discontinue contraception.
Methods:
A cross sectional survey was conducted among women with no history of bleeding.
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